Brugada syndrome associated with an autonomic disorder

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Cardiac autonomic dysfunction in Brugada syndrome.

BACKGROUND Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by change...

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Brugada syndrome--an update.

A diagnostic triad characterizes Brugada syndrome. It consists of a right bundle branch block, ST-segment elevation in leads V1-V3 and sudden cardiac death (SCD). Approximately 50% of patients with Brugada syndrome noted to have familial occurrence, this suggests a genetic component of the disease. Mutations in gene SCN5A, an encoder for human cardiac sodium channel on chromosome 3p21, causes B...

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The Brugada Syndrome: A Rare Arrhythmia Disorder with Complex Inheritance

For the last 10 years, applying new sequencing technologies to thousands of whole exomes has revealed the high variability of the human genome. Extreme caution should thus be taken to avoid misinterpretation when associating rare genetic variants to disease susceptibility. The Brugada syndrome (BrS) is a rare inherited arrhythmia disease associated with high risk of sudden cardiac death in the ...

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Brugada syndrome: an intriguing phenomenon

V Anantharaman, MBBS, FRCS(Edin)(A&E), FAMS Brugada Syndrome has a unique electrocardiographic pattern of downsloping ST-segment elevation in the right praecordial leads (V1 to V3), right bundle branch block pattern and a normal QT-interval. Intermittent and concealed forms do exist. It is important for emergency physicians to recognise this ECG marker of sudden cardiac death. We report the cas...

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Since it was first described approximately 15 years ago, the Brugada Syndrome has spurred a significant quantity of interest in its underlying mechanism and physiology. The Brugada electrocardiographic pattern is characterized by right bundle branch block morphology and ST segment elevations in the right precordial leads with an absence of identifiable underlying structural heart disease. The s...

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ژورنال

عنوان ژورنال: Heart

سال: 1998

ISSN: 1355-6037

DOI: 10.1136/hrt.80.2.194